Activation of The Phosphatidylcholine to Lysophosphatidylcholine Pathway Is Associated with Osteoarthritis Knee Cartilage Volume Loss Over Time

To identify serum biomarker(s) for predicting knee cartilage volume loss over time, we studied 139 knee osteoarthritis (OA) patients from a previous 24-month clinical trial cohort. Targeted metabolomic profiling was performed on serum collected at baseline. The pairwise metabolite ratios as proxies...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Zhai, Guangju, Pelletier, Jean-Pierre, Liu, Ming, Aitken, Dawn, Randell, Edward, Rahman, Proton, Jones, Graeme, Martel-Pelletier, Johanne
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609700/
https://ncbi.nlm.nih.gov/pubmed/31273319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46185-w
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