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Histidine at position 462 determines the low quinine sensitivity of ether‐à‐go‐go channel superfamily member K(v)12.1
BACKGROUND AND PURPOSE: The ether‐à‐go‐go (Eag) K(v) superfamily comprises closely related K(v)10, K(v)11, and K(v)12 subunits. K(v)11.1 (termed hERG in humans) gained much attention, as drug‐induced inhibition of these channels is a frequent cause of sudden death in humans. The exclusive drug sensi...
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| Udgivet i: | Br J Pharmacol |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6609544/ https://ncbi.nlm.nih.gov/pubmed/31032878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14693 |
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