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The conformation and dynamics of P-glycoprotein in a lipid bilayer investigated by atomic force microscopy
The membrane-bound P-glycoprotein (Pgp) transporter plays a major role in human disease and drug disposition because of its ability to efflux a chemically diverse range of drugs through ATP hydrolysis and ligand-induced conformational changes. Deciphering these structural changes is key to understan...
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| 發表在: | Biochem Pharmacol |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6609289/ https://ncbi.nlm.nih.gov/pubmed/30121251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2018.08.017 |
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