Identification of Mutations in the mrdA Gene Encoding PBP2 That Reduce Carbapenem and Diazabicyclooctane Susceptibility of Escherichia coli Clinical Isolates with Mutations in ftsI (PBP3) and Which Carry bla(NDM-1)

Penicillin-binding proteins (PBPs) are essential for bacterial cell wall biosynthesis, and several are clinically validated antibacterial targets of β-lactam antibiotics. We identified mutations in the mrdA gene encoding the PBP2 protein in two Escherichia coli bla(NDM-1) clinical isolates that redu...

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Detalhes bibliográficos
Publicado no:mSphere
Main Authors: Ranjitkar, Srijan, Reck, Folkert, Ke, Xiaobo, Zhu, Qingming, McEnroe, Glenn, Lopez, Sara L., Dean, Charles R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Observation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6609223/
https://ncbi.nlm.nih.gov/pubmed/31270174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00074-19
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