Proteomic Survey Reveals Altered Energetic Patterns and Metabolic Failure Prior to Retinal Degeneration

Inherited mutations that lead to misfolding of the visual pigment rhodopsin (Rho) are a prominent cause of photoreceptor neuron (PN) degeneration and blindness. How Rho proteotoxic stress progressively impairs PN viability remains unknown. To identify the pathways that mediate Rho toxicity in PNs, w...

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發表在:J Neurosci
Main Authors: Griciuc, Ana, Roux, Michel J., Merl, Juliane, Giangrande, Angela, Hauck, Stefanie M., Aron, Liviu, Ueffing, Marius
格式: Artigo
語言:Inglês
出版: Society for Neuroscience 2014
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608515/
https://ncbi.nlm.nih.gov/pubmed/24553922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2982-13.2014
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