Mutant α-Synuclein Enhances Firing Frequencies in Dopamine Substantia Nigra Neurons by Oxidative Impairment of A-Type Potassium Channels

Parkinson disease (PD) is an α-synucleinopathy resulting in the preferential loss of highly vulnerable dopamine (DA) substantia nigra (SN) neurons. Mutations (e.g., A53T) in the α-synuclein gene (SNCA) are sufficient to cause PD, but the mechanism of their selective action on vulnerable DA SN neuron...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Subramaniam, Mahalakshmi, Althof, Daniel, Gispert, Suzana, Schwenk, Jochen, Auburger, Georg, Kulik, Akos, Fakler, Bernd, Roeper, Jochen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608377/
https://ncbi.nlm.nih.gov/pubmed/25297088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5069-13.2014
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