Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum

The cause of degeneration of nigrostriatal dopamine (DA) neurons in idiopathic Parkinson's disease (PD) is still unknown. Intraneuronally, DA is largely confined to synaptic vesicles where it is protected from metabolic breakdown. In the cytoplasm, however, free DA can give rise to formation of...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Pifl, Christian, Rajput, Alex, Reither, Harald, Blesa, Javier, Cavada, Carmen, Obeso, José A., Rajput, Ali H., Hornykiewicz, Oleh
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608236/
https://ncbi.nlm.nih.gov/pubmed/24920625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5456-13.2014
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