Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1(−/Δ7) mice

With aging, tryptophan metabolism is affected. Tryptophan has a crucial role in the induction of immune tolerance and the maintenance of gut microbiota. We, therefore, studied the effect of dietary tryptophan restriction in young wild‐type (WT) mice (118‐wk life span) and in DNA‐repair deficient, pr...

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Bibliografiske detaljer
Udgivet i:J Leukoc Biol
Main Authors: van Beek, Adriaan A., Hugenholtz, Floor, Meijer, Ben, Sovran, Bruno, Perdijk, Olaf, Vermeij, Wilbert P., Brandt, Renata M. C., Barnhoorn, Sander, Hoeijmakers, Jan H. J., de Vos, Paul, Leenen, Pieter J. M., Hendriks, Rudi W., Savelkoul, Huub F. J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Spotlight on Leading Edge Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608003/
https://ncbi.nlm.nih.gov/pubmed/27418353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1HI0216-062RR
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