Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1(−/Δ7) mice

With aging, tryptophan metabolism is affected. Tryptophan has a crucial role in the induction of immune tolerance and the maintenance of gut microbiota. We, therefore, studied the effect of dietary tryptophan restriction in young wild‐type (WT) mice (118‐wk life span) and in DNA‐repair deficient, pr...

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Detalhes bibliográficos
Publicado no:J Leukoc Biol
Main Authors: van Beek, Adriaan A., Hugenholtz, Floor, Meijer, Ben, Sovran, Bruno, Perdijk, Olaf, Vermeij, Wilbert P., Brandt, Renata M. C., Barnhoorn, Sander, Hoeijmakers, Jan H. J., de Vos, Paul, Leenen, Pieter J. M., Hendriks, Rudi W., Savelkoul, Huub F. J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Spotlight on Leading Edge Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608003/
https://ncbi.nlm.nih.gov/pubmed/27418353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.1HI0216-062RR
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