C-terminal and full length TDP-43 specie differ according to FTLD-TDP lesion type but not genetic mutation

The transactive response DNA binding protein of 43 kDa (TDP-43) is an intranuclear protein involved in RNA splicing. Abnormally deposited TDP-43 is found in the brains of patients with frontotemporal lobar degeneration (FTLD). Different morphological characteristics of TDP-43 immunoreactive inclusio...

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Bibliographic Details
Published in:Acta Neuropathol Commun
Main Authors: Josephs, Keith A., Zhang, Yong-Jie, Baker, Matthew, Rademakers, Rosa, Petrucelli, Leonard, Dickson, Dennis W.
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6607585/
https://ncbi.nlm.nih.gov/pubmed/31266542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0755-x
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