Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains

TDP-43 is present in a high proportion of aged brains that do not meet criteria for frontotemporal lobar degeneration (FTLD). We determined whether there are distinct TDP-43 types in non-FTLD brains. From a cohort of 553 brains (Braak neurofibrillary tangle (NFT) stage 0-VI), excluding cases meeting...

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Vydáno v:Acta Neuropathol
Hlavní autoři: Josephs, Keith A., Murray, Melissa E., Tosakulwong, Nirubol, Weigand, Stephen D., Serie, Amanda M., Perkerson, Ralph B., Matchett, Billie J., Jack, Clifford R., Knopman, David S., Petersen, Ronald C., Parisi, Joseph E., Petrucelli, Leonard, Baker, Matthew, Rademakers, Rosa, Whitwell, Jennifer L., Dickson, Dennis W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358471/
https://ncbi.nlm.nih.gov/pubmed/30604226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-018-1951-7
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