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Enhancement of Adeno-Associated Virus-Mediated Gene Therapy Using Hydroxychloroquine in Murine and Human Tissues

The therapeutic effects of gene therapy using adeno-associated virus (AAV) vectors are dependent on the efficacy of viral transduction. Currently, we have reached the safe limits of AAV vector dose, beyond which damaging inflammatory responses are seen. To improve the efficacy of AAV transduction, w...

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Publicado en:Mol Ther Methods Clin Dev
Main Authors: Chandler, Laurel C., Barnard, Alun R., Caddy, Sarah L., Patrício, Maria I., McClements, Michelle E., Fu, Howell, Rada, Cristina, MacLaren, Robert E., Xue, Kanmin
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606965/
https://ncbi.nlm.nih.gov/pubmed/31309129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.05.012
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