MBNL1 overexpression is not sufficient to rescue the phenotypes in a mouse model of RNA toxicity

Myotonic dystrophy type 1 (DM1) is caused by an expanded (CTG)(n) tract in the 3′UTR of the DM protein kinase (DMPK) gene. The RNA transcripts produced from the expanded allele sequester or alter the function of RNA-binding proteins (MBNL1, CUGBP1, etc.). The sequestration of MBNL1 results in RNA-sp...

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Udgivet i:Hum Mol Genet
Main Authors: Yadava, Ramesh S, Kim, Yun K, Mandal, Mahua, Mahadevan, Karunasai, Gladman, Jordan T, Yu, Qing, Mahadevan, Mani S
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
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General Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606845/
https://ncbi.nlm.nih.gov/pubmed/30997488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz065
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