Disease Phenotypes in a Mouse Model of RNA Toxicity Are Independent of Protein Kinase Cα and Protein Kinase Cβ

Myotonic dystrophy type 1(DM1) is the prototype for diseases caused by RNA toxicity. RNAs from the mutant allele contain an expanded (CUG)(n) tract within the 3' untranslated region of the dystrophia myotonica protein kinase (DMPK) gene. The toxic RNAs affect the function of RNA binding protein...

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Опубликовано в: :PLoS One
Главные авторы: Kim, Yun K., Yadava, Ramesh S., Mandal, Mahua, Mahadevan, Karunasai, Yu, Qing, Leitges, Michael, Mahadevan, Mani S.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033491/
https://ncbi.nlm.nih.gov/pubmed/27657532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163325
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