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Nasal delivery of donepezil HCl-loaded hydrogels for the treatment of Alzheimer’s disease
This study aims to prepare, characterize and evaluate the pharmacokinetics of liposomal donepezil HCl (LDH) dispersed into thiolated chitosan hydrogel (TCH) in rabbits. Various hydrogels including TCH were prepared, and after characterization, TCH was selected for subsequent evaluations, due to the...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6606601/ https://ncbi.nlm.nih.gov/pubmed/31266990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46032-y |
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