Lin28B and Let-7 in the Control of Sympathetic Neurogenesis and Neuroblastoma Development

The RNA binding protein Lin28B is expressed in developing tissues and sustains stem and progenitor cell identity as a negative regulator of the Let-7 family of microRNAs, which induces differentiation. Lin28B is activated in neuroblastoma (NB), a childhood tumor in sympathetic ganglia and adrenal me...

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Publié dans:J Neurosci
Auteurs principaux: Hennchen, Melanie, Stubbusch, Jutta, Abarchan-El Makhfi, Ikram, Kramer, Marco, Deller, Thomas, Pierre-Eugene, Cécile, Janoueix-Lerosey, Isabelle, Delattre, Olivier, Ernsberger, Uwe, Schulte, Johannes B., Rohrer, Hermann
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2015
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605513/
https://ncbi.nlm.nih.gov/pubmed/26674877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2560-15.2015
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