Nurr1 and Retinoid X Receptor Ligands Stimulate Ret Signaling in Dopamine Neurons and Can Alleviate α-Synuclein Disrupted Gene Expression

α-synuclein, a protein enriched in Lewy bodies and highly implicated in neurotoxicity in Parkinson's disease, is distributed both at nerve terminals and in the cell nucleus. Here we show that a nuclear derivative of α-synuclein induces more pronounced changes at the gene expression level in mou...

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Publicado en:J Neurosci
Autores principales: Volakakis, Nikolaos, Tiklova, Katarina, Decressac, Mickael, Papathanou, Maria, Mattsson, Bengt, Gillberg, Linda, Nobre, André, Björklund, Anders, Perlmann, Thomas
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2015
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605427/
https://ncbi.nlm.nih.gov/pubmed/26490873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1155-15.2015
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