Brain Oxygen Extraction by Using MRI in Older Individuals: Relationship to Apolipoprotein E Genotype and Amyloid Burden

BACKGROUND: Apolipoprotein E4 (APOE4) is a major genetic risk factor for late-onset Alzheimer disease. However, the mechanisms by which APOE4 affects the brain, underpinning this risk, have not been fully elucidated. PURPOSE: To investigate the influence of APOE4 on global cerebral oxygen extraction...

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Detalhes bibliográficos
Publicado no:Radiology
Main Authors: Lin, Zixuan, Sur, Sandeepa, Soldan, Anja, Pettigrew, Corinne, Miller, Michael, Oishi, Kenichi, Bilgel, Murat, Moghekar, Abhay, Pillai, Jay J., Albert, Marilyn, Lu, Hanzhang
Formato: Artigo
Idioma:Inglês
Publicado em: Radiological Society of North America 2019
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604795/
https://ncbi.nlm.nih.gov/pubmed/31012816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1148/radiol.2019182726
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