Immuno-PET Imaging to Assess Target Engagement: Experience from (89)Zr-Anti-HER3 mAb (GSK2849330) in Patients with Solid Tumors

PET imaging with radiolabeled drugs provides information on tumor uptake and dose-dependent target interaction to support selection of an optimal dose for future efficacy testing. In this immuno-PET study of the anti–human epidermal growth factor receptor (HER3) mAb GSK2849330, we investigated the b...

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Detalhes bibliográficos
Publicado no:J Nucl Med
Main Authors: Menke-van der Houven van Oordt, C. Willemien, McGeoch, Adam, Bergstrom, Mats, McSherry, Iain, Smith, Deborah A., Cleveland, Matthew, Al-Azzam, Wasfi, Chen, Liangfu, Verheul, Henk, Hoekstra, Otto S., Vugts, Danielle J., Freedman, Immanuel, Huisman, Marc, Matheny, Chris, van Dongen, Guus, Zhang, Sean
Formato: Artigo
Idioma:Inglês
Publicado em: Society of Nuclear Medicine 2019
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6604691/
https://ncbi.nlm.nih.gov/pubmed/30733323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.118.214726
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