Combination of apoptotic T cell induction and self-peptide administration for therapy of experimental autoimmune encephalomyelitis

BACKGROUND: Clinical trials on multiple sclerosis with repeated injections of monoclonal antibodies depleting CD4(+) T cells have not resulted in much success as a disease therapy. Here, we developed an immunotherapy for EAE in mice by combining a transient depletion of T cells together with the adm...

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Bibliographische Detailangaben
Veröffentlicht in:EBioMedicine
Hauptverfasser: Kasagi, Shimpei, Wang, Dandan, Zhang, Pin, Zanvit, Peter, Chen, Hua, Zhang, Dunfang, Li, Jia, Che, Li, Maruyama, Takashi, Nakatsukasa, Hiroko, Wu, Ruiqing, Jin, Wenwen, Sun, Lingyun, Chen, WanJun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
Schlagworte:
Research paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6603850/
https://ncbi.nlm.nih.gov/pubmed/31097410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.05.005
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