Pharmacologic treatment with CPI-613 and PS48 decreases mitochondrial membrane potential and increases quantity of autolysosomes in porcine fibroblasts

A metabolic phenomenon known as the Warburg effect has been characterized in certain cancerous cells, embryonic stem cells, and other rapidly proliferative cell types. Previously, our attempts to induce a Warburg-like state pharmaceutically via CPI-613 and PS48 treatment did augment metabolite produ...

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Publicado no:Sci Rep
Main Authors: Mordhorst, Bethany R., Kerns, Karl C., Schauflinger, Martin, Zigo, Michal, Murphy, Stephanie L., Ross, Renee M., Wells, Kevin D., Green, Jonathan A., Sutovsky, Peter, Prather, Randall S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6603033/
https://ncbi.nlm.nih.gov/pubmed/31263141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45850-4
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