Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations

The HIV-1 envelope (Env) is the target for neutralizing antibodies and exists on the surface of virions in open or closed conformations. Difficult-to-neutralize viruses (tier 2) express Env in a closed conformation antigenic for broadly neutralizing antibodies (bnAbs) but not for third variable regi...

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Publicado en:Nat Commun
Main Authors: Han, Qifeng, Jones, Julia A., Nicely, Nathan I., Reed, Rachel K., Shen, Xiaoying, Mansouri, Katayoun, Louder, Mark, Trama, Ashley M., Alam, S. Munir, Edwards, Robert J., Bonsignori, Mattia, Tomaras, Georgia D., Korber, Bette, Montefiori, David C., Mascola, John R., Seaman, Michael S., Haynes, Barton F., Saunders, Kevin O.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602974/
https://ncbi.nlm.nih.gov/pubmed/31263112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10899-2
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