Retinoic acid and arsenic trioxide induce lasting differentiation and demethylation of target genes in APL cells

Acute promyelocytic leukemia (APL) is characterized by arrested differentiation of promyelocytes. Patients treated with all-trans retinoic acid (ATRA) alone experience relapse, while patients treated with ATRA and arsenic trioxide (ATO) are often relapse-free. This suggests sustained changes have be...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Huynh, Thomas T., Sultan, Mohammad, Vidovic, Dejan, Dean, Cheryl A., Cruickshank, Brianne M., Lee, Kristen, Loung, Chao-Yu, Holloway, Ryan W., Hoskin, David W., Waisman, David M., Weaver, Ian C. G., Marcato, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602962/
https://ncbi.nlm.nih.gov/pubmed/31263158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45982-7
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