Retinoic acid and arsenic trioxide induce lasting differentiation and demethylation of target genes in APL cells

Acute promyelocytic leukemia (APL) is characterized by arrested differentiation of promyelocytes. Patients treated with all-trans retinoic acid (ATRA) alone experience relapse, while patients treated with ATRA and arsenic trioxide (ATO) are often relapse-free. This suggests sustained changes have be...

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Udgivet i:Sci Rep
Main Authors: Huynh, Thomas T., Sultan, Mohammad, Vidovic, Dejan, Dean, Cheryl A., Cruickshank, Brianne M., Lee, Kristen, Loung, Chao-Yu, Holloway, Ryan W., Hoskin, David W., Waisman, David M., Weaver, Ian C. G., Marcato, Paola
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602962/
https://ncbi.nlm.nih.gov/pubmed/31263158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45982-7
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