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Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration

Intervertebral disc (IVD) degeneration is known to aggravate with age and oxidative stress is implicated in the pathogenesis of many age-related diseases. Nuclear factor (erythroid-derived-2)-like 2 (Nrf2) can confer adaptive protection against oxidative and proteotoxic stress in cells. In this stud...

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Dades bibliogràfiques
Publicat a:Cell Death Dis
Autors principals: Tang, Zehan, Hu, Bo, Zang, Fazhi, Wang, Jianxi, Zhang, Xingda, Chen, Huajiang
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602960/
https://ncbi.nlm.nih.gov/pubmed/31263165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1701-3
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