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Opioids: keeping the good, eliminating the bad

Two new studies show that mechanisms mediating the opioid side effects of tolerance, hyperalgesia and physical dependence are mediated spinally and can be dissociated from analgesia. These side effects can be selectively targeted by clinically available drugs without affecting their pain-relieving e...

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Bibliografski detalji
Izdano u:Nat Med
Glavni autori: Puig, Stephanie, Gutstein, Howard B
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602584/
https://ncbi.nlm.nih.gov/pubmed/28134927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4277
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