Heterogeneity of transposon expression and activation of the repressive network in human fetal germ cells

Epigenetic resetting in germ cells during development de-represses transposable elements (TEs). piRNAs protect fetal germ cells by targeted mRNA destruction and deposition of repressive epigenetic marks. Here, we provide the first evidence for an active piRNA pathway and TE repression in germ cells...

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Detalhes bibliográficos
Publicado no:Development
Main Authors: Reznik, Boris, Cincotta, Steven A., Jaszczak, Rebecca G., Mateo, Leslie J., Shen, Joel, Cao, Mei, Baskin, Laurence, Ye, Ping, An, Wenfeng, Laird, Diana J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
Assuntos:
Human Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602354/
https://ncbi.nlm.nih.gov/pubmed/30658985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.171157
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