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Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation

Congenital heart defects affect ∼2% of live births and often involve malformations of the semilunar (aortic and pulmonic) valves. We previously reported a highly penetrant GATA4 p.Gly296Ser mutation in familial, congenital atrial septal defects and pulmonic valve stenosis and showed that mice harbor...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Dis Model Mech
Hauptverfasser: LaHaye, Stephanie, Majumdar, Uddalak, Yasuhara, Jun, Koenig, Sara N., Matos-Nieves, Adrianna, Kumar, Rahul, Garg, Vidu
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602309/
https://ncbi.nlm.nih.gov/pubmed/31138536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.036764
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