Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption

Monoacylglycerol lipase (MGL) is the rate-limiting enzyme in the degradation of monoacylglycerols. To examine the role of MGL in hepatic steatosis, WT and MGL KO (MGL(−/−)) mice were challenged with a Western diet (WD) over 12 weeks. Lipid metabolism, inflammation, and fibrosis were assessed by seru...

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Publicado en:J Lipid Res
Autores principales: Tardelli, Matteo, Bruschi, Francesca V., Claudel, Thierry, Fuchs, Claudia D., Auer, Nicole, Kunczer, Victoria, Stojakovic, Tatjana, Scharnagl, Hubert, Habib, Aida, Grabner, Gernot F., Zimmermann, Robert, Lotersztajn, Sophie, Trauner, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2019
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602129/
https://ncbi.nlm.nih.gov/pubmed/31048404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M093369
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