Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies

T-cell-recruiting bispecific antibodies (T-BsAbs) have shown potent tumor killing activity in humans, but cytokine release-related toxicities have affected their clinical utility. The use of novel anti-CD3 binding domains with more favorable properties could aid in the creation of T-BsAbs with impro...

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Vydáno v:MAbs
Hlavní autoři: Trinklein, Nathan D., Pham, Duy, Schellenberger, Ute, Buelow, Ben, Boudreau, Andrew, Choudhry, Priya, Clarke, Starlynn C., Dang, Kevin, Harris, Katherine E., Iyer, Suhasini, Jorgensen, Brett, Pratap, Payal P., Rangaswamy, Udaya S., Ugamraj, Harshad S., Vafa, Omid, Wiita, Arun P., van Schooten, Wim, Buelow, Roland, Force Aldred, Shelley
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2019
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Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601548/
https://ncbi.nlm.nih.gov/pubmed/30698484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1574521
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