Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies

We created a novel transgenic rat that expresses human antibodies comprising a diverse repertoire of heavy chains with a single common rearranged kappa light chain (IgKV3-15-JK1). This fixed light chain animal, called OmniFlic, presents a unique system for human therapeutic antibody discovery and a...

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Udgivet i:Front Immunol
Main Authors: Harris, Katherine E., Aldred, Shelley Force, Davison, Laura M., Ogana, Heather Anne N., Boudreau, Andrew, Brüggemann, Marianne, Osborn, Michael, Ma, Biao, Buelow, Benjamin, Clarke, Starlynn C., Dang, Kevin H., Iyer, Suhasini, Jorgensen, Brett, Pham, Duy T., Pratap, Payal P., Rangaswamy, Udaya S., Schellenberger, Ute, van Schooten, Wim C., Ugamraj, Harshad S., Vafa, Omid, Buelow, Roland, Trinklein, Nathan D.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928204/
https://ncbi.nlm.nih.gov/pubmed/29740455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00889
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