Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies

We created a novel transgenic rat that expresses human antibodies comprising a diverse repertoire of heavy chains with a single common rearranged kappa light chain (IgKV3-15-JK1). This fixed light chain animal, called OmniFlic, presents a unique system for human therapeutic antibody discovery and a...

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書誌詳細
出版年:Front Immunol
主要な著者: Harris, Katherine E., Aldred, Shelley Force, Davison, Laura M., Ogana, Heather Anne N., Boudreau, Andrew, Brüggemann, Marianne, Osborn, Michael, Ma, Biao, Buelow, Benjamin, Clarke, Starlynn C., Dang, Kevin H., Iyer, Suhasini, Jorgensen, Brett, Pham, Duy T., Pratap, Payal P., Rangaswamy, Udaya S., Schellenberger, Ute, van Schooten, Wim C., Ugamraj, Harshad S., Vafa, Omid, Buelow, Roland, Trinklein, Nathan D.
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2018
主題:
Immunology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928204/
https://ncbi.nlm.nih.gov/pubmed/29740455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00889
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