Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies

Heavy chain-only antibodies (HCAbs) do not associate with light chains and their V(H) regions are functional as single domains, forming the smallest active antibody fragment. These V(H) regions are ideal building blocks for a variety of antibody-based biologics because they tolerate fusion to other...

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Veröffentlicht in:Front Immunol
Hauptverfasser: Clarke, Starlynn C., Ma, Biao, Trinklein, Nathan D., Schellenberger, Ute, Osborn, Michael J., Ouisse, Laure-Hélène, Boudreau, Andrew, Davison, Laura M., Harris, Katherine E., Ugamraj, Harshad S., Balasubramani, Aarti, Dang, Kevin H., Jorgensen, Brett, Ogana, Heather Anne N., Pham, Duy T., Pratap, Payal P., Sankaran, Preethi, Anegon, Ignacio, van Schooten, Wim C., Brüggemann, Marianne, Buelow, Roland, Force Aldred, Shelley
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330309/
https://ncbi.nlm.nih.gov/pubmed/30666250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.03037
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