PRCD is essential for high-fidelity photoreceptor disc formation

Progressive rod-cone degeneration (PRCD) is a small protein residing in the light-sensitive disc membranes of the photoreceptor outer segment. Until now, the function of PRCD has remained enigmatic despite multiple demonstrations that its mutations cause blindness in humans and dogs. Here, we genera...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Spencer, William J., Ding, Jin-Dong, Lewis, Tylor R., Yu, Chen, Phan, Sebastien, Pearring, Jillian N., Kim, Keun-Young, Thor, Andrea, Mathew, Rose, Kalnitsky, Joan, Hao, Ying, Travis, Amanda M., Biswas, Sondip K., Lo, Woo-Kuen, Besharse, Joseph C., Ellisman, Mark H., Saban, Daniel R., Burns, Marie E., Arshavsky, Vadim Y.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601265/
https://ncbi.nlm.nih.gov/pubmed/31189593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906421116
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