PRCD is essential for high-fidelity photoreceptor disc formation

Progressive rod-cone degeneration (PRCD) is a small protein residing in the light-sensitive disc membranes of the photoreceptor outer segment. Until now, the function of PRCD has remained enigmatic despite multiple demonstrations that its mutations cause blindness in humans and dogs. Here, we genera...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Spencer, William J., Ding, Jin-Dong, Lewis, Tylor R., Yu, Chen, Phan, Sebastien, Pearring, Jillian N., Kim, Keun-Young, Thor, Andrea, Mathew, Rose, Kalnitsky, Joan, Hao, Ying, Travis, Amanda M., Biswas, Sondip K., Lo, Woo-Kuen, Besharse, Joseph C., Ellisman, Mark H., Saban, Daniel R., Burns, Marie E., Arshavsky, Vadim Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601265/
https://ncbi.nlm.nih.gov/pubmed/31189593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906421116
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