Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension

Chronic hypoxia causes pulmonary hypertension (PH), vascular remodeling, right ventricular (RV) hypertrophy, and cardiac failure. Protein kinase G Iα (PKGIα) is susceptible to oxidation, forming an interprotein disulfide homodimer associated with kinase targeting involved in vasodilation. Here we re...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Rudyk, Olena, Rowan, Alice, Prysyazhna, Oleksandra, Krasemann, Susanne, Hartmann, Kristin, Zhang, Min, Shah, Ajay M., Ruppert, Clemens, Weiss, Astrid, Schermuly, Ralph T., Ida, Tomoaki, Akaike, Takaaki, Zhao, Lan, Eaton, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601250/
https://ncbi.nlm.nih.gov/pubmed/31186362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904064116
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