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Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1α knock-in mouse
BACKGROUND: Although nitroglycerin has remained in clinical use since 1879 the mechanism by which it relaxes blood vessels to lower blood pressure remains incompletely understood. Nitroglycerin undergoes metabolism generating several reaction products, including oxidants, and this ‘bioactivation’ pr...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3617728/ https://ncbi.nlm.nih.gov/pubmed/22685118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.101287 |
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