A spontaneous leptin receptor point mutation causes obesity and differentially affects leptin signaling in hypothalamic nuclei resulting in metabolic dysfunctions distinct from db/db mice

OBJECTIVE: Leptin (Lep) plays a crucial role in controlling food intake and energy expenditure. Defective Lep/LepRb-signaling leads to fat accumulation, massive obesity, and the development of diabetes. We serendipitously noticed spontaneous development of obesity similar to LepR-deficient (db/db) m...

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Pubblicato in:Mol Metab
Autori principali: Piattini, Federica, Le Foll, Christelle, Kisielow, Jan, Rosenwald, Esther, Nielsen, Peter, Lutz, Thomas, Schneider, Christoph, Kopf, Manfred
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601129/
https://ncbi.nlm.nih.gov/pubmed/31076350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2019.04.010
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