Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients

The emergence of treatment resistant sub-clones is a key feature of relapse in multiple myeloma. Therapeutic attempts to extend remission and prevent relapse include maximizing response and the use of maintenance therapy. We used whole exome sequencing to study the genetics of paired samples taken a...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Jones, John R., Weinhold, Niels, Ashby, Cody, Walker, Brian A., Wardell, Chris, Pawlyn, Charlotte, Rasche, Leo, Melchor, Lorenzo, Cairns, David A., Gregory, Walter M., Johnson, David, Begum, Dil B., Ellis, Sidra, Sherborne, Amy L., Cook, Gordon, Kaiser, Martin F., Drayson, Mark T., Owen, Roger G., Jackson, Graham H., Davies, Faith E., Greaves, Mel, Morgan, Gareth J.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601103/
https://ncbi.nlm.nih.gov/pubmed/30733268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.202200
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