ERG deletions in childhood acute lymphoblastic leukemia with DUX4 rearrangements are mostly polyclonal, prognostically relevant and their detection rate strongly depends on screening method sensitivity

ERG-deletions occur recurrently in acute lymphoblastic leukemia, especially in the DUX4-rearranged subtype. The ERG-deletion was shown to positively impact prognosis of patients with IKZF1-deletion and its presence precludes assignment into IKZF1(plus) group, a novel high-risk category on AIEOP-BFM...

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Publicado en:Haematologica
Autores principales: Zaliova, Marketa, Potuckova, Eliska, Hovorkova, Lenka, Musilova, Alena, Winkowska, Lucie, Fiser, Karel, Stuchly, Jan, Mejstrikova, Ester, Starkova, Julia, Zuna, Jan, Stary, Jan, Trka, Jan
Formato: Artigo
Lenguaje:Inglês
Publicado: Ferrata Storti Foundation 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601096/
https://ncbi.nlm.nih.gov/pubmed/30630977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.204487
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