LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells

Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and is implicated in leukemogenesis. Nuclear-localized β-catenin is indicative of active Wnt signaling and is frequently observed in acute myeloid leukemia (AML) patients; however, some patients exhibit little or no nu...

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Veröffentlicht in:Haematologica
Hauptverfasser: Morgan, Rhys G., Ridsdale, Jenna, Payne, Megan, Heesom, Kate J., Wilson, Marieangela C., Davidson, Andrew, Greenhough, Alexander, Davies, Sara, Williams, Ann C., Blair, Allison, Waterman, Marian L., Tonks, Alex, Darley, Richard L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601079/
https://ncbi.nlm.nih.gov/pubmed/30630973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.202846
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