LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells

Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and is implicated in leukemogenesis. Nuclear-localized β-catenin is indicative of active Wnt signaling and is frequently observed in acute myeloid leukemia (AML) patients; however, some patients exhibit little or no nu...

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Udgivet i:Haematologica
Main Authors: Morgan, Rhys G., Ridsdale, Jenna, Payne, Megan, Heesom, Kate J., Wilson, Marieangela C., Davidson, Andrew, Greenhough, Alexander, Davies, Sara, Williams, Ann C., Blair, Allison, Waterman, Marian L., Tonks, Alex, Darley, Richard L.
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601079/
https://ncbi.nlm.nih.gov/pubmed/30630973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.202846
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