N(ɛ)-acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors

HDAC inhibitors have been developed very rapidly in clinical trials and even in approvals for treating several cancers. However, there are few reported HDAC inhibitors designed from N(ɛ)-acetyl lysine. In the current study, we raised a novel design, which concerns N(ɛ)-acetyl lysine derivatives cont...

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Vydáno v:R Soc Open Sci
Hlavní autoři: Wang, Fang, Wang, Chun, Wang, Jie, Zou, Yefang, Chen, Xiaoxue, Liu, Ting, Li, Yan, Zhao, Yonglong, Li, Yongjun, He, Bin
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society 2019
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599804/
https://ncbi.nlm.nih.gov/pubmed/31312496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsos.190338
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