A Rapid Bead-Based Radioligand Binding Assay for the Determination of Target-Binding Fraction and Quality Control of Radiopharmaceuticals

INTRODUCTION: Determination of the target-binding fraction (TBF) of radiopharmaceuticals using cell-based assays is prone to inconsistencies arising from several intrinsic and extrinsic factors. Here, we report a cell-free quantitative method of analysis to determine the TBF of radioligands. METHODS...

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Veröffentlicht in:Nucl Med Biol
Hauptverfasser: Sharma, Sai Kiran, Lyaschenko, Serge K., Park, Hijin A., Pillarsetty, Nagavarakishore, Roux, Yorann, Wu, Jiong, Poty, Sophie, Tully, Kathryn M., Poirier, John T., Lewis, Jason S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599726/
https://ncbi.nlm.nih.gov/pubmed/31128476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2019.04.005
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