Site-specifically labeled (89)Zr-DFO-trastuzumab improves immuno-reactivity and tumor uptake for immuno-PET in a subcutaneous HER2-positive xenograft mouse model

Antibody-based PET tracers are exceptionally well-suited for determination of the in vivo biodistribution and quantification of therapeutic antibodies. The continued expansion in antibody-based therapeutics has accordingly driven the development towards more robust conjugation strategies in order to...

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Udgivet i:Theranostics
Main Authors: Kristensen, Lotte K., Christensen, Camilla, Jensen, Mette M., Agnew, Brian J., Schjöth-Frydendahl, Christina, Kjaer, Andreas, Nielsen, Carsten H.
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599660/
https://ncbi.nlm.nih.gov/pubmed/31285769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.32883
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