Electrophysiologic and Molecular Mechanisms of a Frameshift NPPA Mutation Linked with Familial Atrial Fibrillation

A frameshift (fs) mutation in the natriuretic peptide precursor A (NPPA) gene, encoding a mutant atrial natriuretic peptide (Mut-ANP), has been linked with familial atrial fibrillation (AF) but the underlying mechanisms by which the mutation causes AF remain unclear. We engineered 2 transgenic (TG)...

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Gepubliceerd in:J Mol Cell Cardiol
Hoofdauteurs: Menon, Ambili, Hong, Liang, Savio-Galimberti, Eleonora, Sridhar, Arvind, Youn, Seock-Won, Zhang, Meihong, Kor, Kaylen, Blair, Marcia, Kupershmidt, Sabina, Darbar, Dawood
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599642/
https://ncbi.nlm.nih.gov/pubmed/31077706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2019.05.004
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