Genomic and transcriptomic profiling expands precision cancer medicine: the WINTHER trial

Precision medicine focuses on DNA abnormalities, but not all tumors have tractable genomic alterations. The WINTHER trial (NCT01856296) navigated patients to therapy on the basis of fresh biopsy-derived DNA sequencing (arm A; 236 gene panel) or RNA expression (arm B; comparing tumor to normal). The...

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Gepubliceerd in:Nat Med
Hoofdauteurs: Rodon, Jordi, Soria, Jean-Charles, Berger, Raanan, Miller, Wilson H., Rubin, Eitan, Kugel, Aleksandra, Tsimberidou, Apostolia, Saintigny, Pierre, Ackerstein, Aliza, Braña, Irene, Loriot, Yohann, Afshar, Mohammad, Miller, Vincent, Wunder, Fanny, Bresson, Catherine, Martini, Jean-François, Raynaud, Jacques, Mendelsohn, John, Batist, Gerald, Onn, Amir, Tabernero, Josep, Schilsky, Richard L., Lazar, Vladimir, Lee, J. Jack, Kurzrock, Razelle
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599610/
https://ncbi.nlm.nih.gov/pubmed/31011205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0424-4
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