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Chiral aminophosphines derived from hydroxyproline and their application in allene–imine [4 + 2] annulation

A robust synthetic route from l-hydroxyproline (l-Hyp) to phosphines has established an expandable library of six chiral aminophosphines, which were then applied to the phosphine-catalyzed [4 + 2] allene–imine annulation. The enantioinduction in the annulations—induced by a purely steric effect—were...

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Bibliografiske detaljer
Udgivet i:J Antibiot (Tokyo)
Main Authors: Khong, San N., Xie, Changmin, Wang, Xinyi, Tan, Hao, Kwon, Ohyun
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599608/
https://ncbi.nlm.nih.gov/pubmed/30940911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41429-019-0181-0
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