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Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia
INTRODUCTION: The chromosomal rearrangements of the mixed-lineage leukemia gene MLL (KMT2A) have been extensively characterized as a potent oncogenic driver in leukemia. For its oncogenic function, most MLL-fusion proteins exploit the multienzyme super elongation complex leading to elevated expressi...
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| Izdano u: | J Hematol Oncol |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BioMed Central
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6599250/ https://ncbi.nlm.nih.gov/pubmed/31253180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-019-0749-y |
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