Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness

Our ability to manage acute myeloid leukemia (AML) is limited by our incomplete understanding of the epigenetic disruption central to leukemogenesis, including improper histone methylation. Here we examine 16 histone H3 genes in 434 primary AML samples and identify Q69H, A26P, R2Q, R8H and K27M/I mu...

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Publicado no:Nat Commun
Main Authors: Boileau, Meaghan, Shirinian, Margret, Gayden, Tenzin, Harutyunyan, Ashot S., Chen, Carol C. L., Mikael, Leonie G., Duncan, Heather M., Neumann, Andrea L., Arreba-Tutusaus, Patricia, De Jay, Nicolas, Zeinieh, Michele, Rossokhata, Katya, Zhang, Yelu, Nikbakht, Hamid, Mouawad, Carine, Massoud, Radwan, Frey, Felice, Nasr, Rihab, El Cheikh, Jean, El Sabban, Marwan, Kleinman, Claudia L., Mahfouz, Rami, Minden, Mark D., Jabado, Nada, Bazarbachi, Ali, Eppert, Kolja
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599207/
https://ncbi.nlm.nih.gov/pubmed/31253791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10705-z
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