Optimal composition and position of histidine-containing tags improves biodistribution of (99m)Tc-labeled DARPin G3

Radionuclide molecular imaging of HER2 expression in disseminated cancer enables stratification of patients for HER2-targeted therapies. DARPin G3, a small (14 kDa) engineered scaffold protein, is a promising probe for imaging of HER2. We hypothesized that position (C- or N-terminus) and composition...

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Udgivet i:Sci Rep
Main Authors: Vorobyeva, Anzhelika, Schulga, Alexey, Konovalova, Elena, Güler, Rezan, Löfblom, John, Sandström, Mattias, Garousi, Javad, Chernov, Vladimir, Bragina, Olga, Orlova, Anna, Tolmachev, Vladimir, Deyev, Sergey M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599047/
https://ncbi.nlm.nih.gov/pubmed/31253840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45795-8
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