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17-Aminogeldanamycin selectively diminishes IRE1α-XBP1s pathway activity and cooperatively induces apoptosis with MEK1/2 and BRAF(V600E) inhibitors in melanoma cells of different genetic subtypes

Outcomes of melanoma patient treatment remain unsatisfactory despite accessibility of oncoprotein-targeting drugs and immunotherapy. Here, we reported that 17-aminogeldanamycin more potently activated caspase-3/7 in BRAF(V600E) melanoma cells than geldanamycin, another inhibitor of heat shock protei...

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Bibliografski detalji
Izdano u:Apoptosis
Glavni autori: Mielczarek-Lewandowska, Aleksandra, Sztiller-Sikorska, Malgorzata, Osrodek, Marta, Czyz, Malgorzata, Hartman, Mariusz L.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2019
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6598962/
https://ncbi.nlm.nih.gov/pubmed/30989459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-019-01542-y
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